Michelle S.
11/8/2025
Guadeloupe on Main delivered a standout family-run dining experience. Our server, who also happened to be the chef's brother, set the tone immediately with warm, genuine hospitality that matched...
The Guadalupe on Main
$$
Closed
(226)
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1526 E Main St
Mesa, AZ 85203
The Guadalupe on Main in Mesa, AZ, offers a craft kitchen and cocktail experience on Main Street. Specializing in flavors from Jalisco, the restaurant provides a gluten-free friendly Mexican menu, inviting guests to savor authentic dishes.
With a focus on quality ingredients and innovative recipes, The Guadalupe on Main aims to create a unique dining experience for patrons seeking a taste of traditional Mexican cuisine with a modern twist.
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Reviews
4.5226 reviews
Crystal Z.
12/11/2025
I saved this place on TikTok to try. We came. We seen. We tried it. Kinda bummed...Let me explain... I ordered the Azteca salad without shrimp. It was good. 7/10 good. Nothing special. The pollo...
Savannah R.
11/23/2025
Okay..WHAT is this hidden gem?! If you haven't been here, stop what you're doing and get over here now. Guadalupe on Main is a Sonoran style Mexican food spot giving off upscale moody upscale...
Denise K.
11/29/2025
The Guadalupe on Main is a beautifully decorated Mexican restaurant. Some dishes were stronger than others, but a few truly stand out--the mole enchiladas and the birria tacos. Pass on the shrimp...
Lenore B.
10/11/2025
Tucked just off the light rail and a quick hop from downtown Mesa, The Guad on Main feels like you've stumbled into your coolest friend's house if your friend also happened to be an artist, chef,...
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