Antagonist Cafe

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2727 S 12th St
Saint Louis, MO 63118

Antagonist Cafe, nestled in the heart of Saint Louis, MO, offers a unique culinary experience for locals and visitors alike. Boasting a prime location just across from the renowned Anheuser-Busch Brewery Tour, this cafe provides a cozy ambiance to enjoy delicious treats.

From delectable pastries to aromatic coffees, Antagonist Cafe serves up a delightful array of menu items to satisfy any craving. Each visit promises a welcoming atmosphere where patrons can indulge in freshly brewed beverages and homemade delicacies.

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Reviews

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4.535 reviews
Photo of Mindy P.
Mindy P.
10/31/2025

What a great spot for coffee! If you are in the area, you have to check it out! I am limiting my caffeine intake so went for some tea, it tasted great and I feel like I got a lot of bang for...

Photo of Kimberly W.
Kimberly W.
10/16/2025

I heard about this place months ago, but didn't get a chance to actually check them out until recently. They are located in a former jail and incorporate this into the theme of the shop, so it's...

Photo of Carri N.
Carri N.
10/1/2025

Well repurposed old police station now cafe and board game businesses occupy this space. Got a Café au lait with a nice creamy foam on top. First time having one of those and it was pretty...

Photo of Whitney D.
Whitney D.
8/24/2025

This old Jail now turned into a coffee shop is very clever. It was my first time here and while walking around there is a little area in the back where you can sit and enjoy your coffee in what is...

Photo of Jade H.
Jade H.
12/4/2025

Shout out to the sister store of my favorite coffee shop Protagonist. Having a dark twin is so cute and I love that they used what was previously a jail house for it! There's ample study room,...

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