Residence Inn Durham McPherson/Duke University Medical Center Area

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1108 W Main St
Durham, NC 27701
+1 (919) 680-4440
https://www.marriott.com
Eat, sleep, and relax at the fully renovated all-suite Residence Inn Durham McPherson/Duke University Medical Center Area. Boasting a prime location near Duke University, North Carolina Central University and Durham Performing Arts Center, our hotel makes it easy to discover some of the area's top attractions. Enjoy spacious suites featuring separate areas for living, cooking and sleeping; and then take in a game at the nearby Durham Bulls Athletic Park or a Broadway production at DPAC. Finish any work tasks you may have using our free Wi-Fi and ergonomic workstation, then prepare yourself a delicious meal with the help of your room's full kitchen. Start your day at our complimentary breakfast buffet. After fueling up, work up a sweat at our fitness center using our cardio equipment and free weights. The hotel offers complimentary transportation services, which must be reserved a minimum 24 hours in advance. Wheelchair accessible transportation is also available.

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4.041 reviews
Photo of Clint R.
Clint R.
11/30/2025

Best two things about this hotel are the staff and the location. Starting with Tiffani at the front desk and then everyone else we encountered in the 9 days we stayed, staff is exceedingly...

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Matt U.
11/9/2025

We were pretty stoked to find a Residence Inn close to the Duke campus when we came back into town for an alumni weekend. This place wasn't here the last time we were in town, but it's a perfect...

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Brittney C.
8/27/2024

I came to this location for my annual family reunion. This was my first time in Durham but not my first time at a residence inn so it helped to find a familiar hotel to stay in. The parking was...

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D M.
1/22/2024

Spacious suites that need a little updating. Display in the lobby stated some interior updates/renovations occurring in the next few months so hopefully this will bring new life to the...

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Veleria L.
7/22/2022

What a quaint and historic looking newly renovated hotel! It's right in the middle of town and only a few miles from Duke University. What I really already love about this hotel is how clean it...

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