Lefty's Main Street Grille

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1410 S Main St
Blacksburg, VA 24060
Lefty's provides SW Virginia with a taste of California inspired cuisine. Lefty's has been in operation since 2004 and moved into a new location in 2016 that includes a brewery and expanded seating.

Reviews

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4.0322 reviews
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Karson S.
9/26/2025

Came here for a work dinner, and was pleasantly surprised at the good quality of the food here! I had the emerald kale salad and it was very good. This is a nicer spot rather than a bar (I wasn't...

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Tiffany H.
10/27/2025

While visiting my daughter at Radford University we wanted to go to brunch. The front desk at my hotel recommend this place. When we got there the wait was 1 hour. But we were willing to wait. We...

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Tom K.
9/8/2025

Locally owned. Visited for lunch. Good number of menu choices. In the past, this restaurant brewed their own beer. But that is no longer available which detracts from the vibe. Lunch was...

Larry H.
10/31/2025

We arrived at 4 pm (at shift change) so was a little slow but not too bad I had pork chops with risotto and mixed vegetables- all were very good My wife had chicken and shrimp tortellini/ also...

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Wayne L.
3/27/2025

Great burger and the Mac & Cheese was to die for. It was walking distance from my hotel so it was ideal for a simple dinner. It was very busy with a good local vibe. The service was good but, I...

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